Orlando’s mayor confirms that 49 people were killed and 53 others were wounded in the deadliest mass shooting in US history.
The death toll makes the attack the deadliest mass shooting in US history, eclipsing the 2007 Virginia Tech massacre which left 32 people dead.
Authorities say they are investigating it as an act of terrorism.
The gunman, who is among the dead, has been named as 29-year-old Omar Mateen of Port St. Lucie Florida.
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Pulse Club posted on its Facebook page: “Everyone get out of Pulse and keep running”.
Orlando Police have urged people to stay away from the area.
Local TV reporter Stewart Moore tweeted that the attacker was still inside the nightclub with hostages, and was feared to be wearing a bomb.
It comes after star of The Voice, Christina Grimmie was shot dead by a deranged fan as she performed at the Plaza Live venue in the city on Friday.
Orlando Police also said in a tweet that the shooter inside the Pulse Club is now dead.
A bomb squad and hazardous material team were at the scene, and a controlled explosion was carried out.
Relatives have been gathering at local hospitals desperate for news.